Chinese Academy of Sciences Guangzhou won new progress in the use of shikimic acid

Shikimic acid ((-)-shikimic acid) is the main water-soluble component in the star anise of China's characteristic strategic resource, and its chemical name is (3R,4S,5R)-trihydroxy-1-cyclohexene-1-carboxylic acid. It is found in dry mature fruits of the Illicium verum Hook.f., which can be as high as 12-14%. China is the main producing country of the world's star anise, and its planting area and production account for more than 80% of the world's total. Since the shikimic acid is mainly obtained from the branches, leaves and fruits of an octagonal tree, its acquisition process does not harm plants and the environment, and modern bioengineering technology has been established with E. coli as a carrier and glucose is used as a raw material and is prepared in high yield. Industrialization of oxalic acid. Therefore, shikimic acid is a truly renewable, non-food biomass resource. However, the application range of shikimic acid has so far been limited. It is mainly used to synthesize the anti-influenza drug Tamiflu, and it is urgent to expand its diversified, high value-use space and further develop it as a renewable resource. Use value.

Researchers at Guangzhou Institute of Chemistry, Guangzhou, China/CAS have studied the aromatization of shikimic acid derivatives involved in primary amines. For the first time, the methodology for aromatization of shikimic acid derived from primary amines has been proposed and preliminarily constructed. It provides new and useful ideas for research in the field of modern green chemistry.

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